ROXADEX

Composition:

Each ml aqueous solution contains:
5 mg of the glucocorticoid dexamethasone sodium phosphate USP

General Description:

Dexamethasone sodium phosphate is rapidly converted into dexamethasone. This is a sythetic glucocorticoid with a 7 times higher anti-inflammatory potency than prednisolone and 30 times that of the natural glucocorticoid, hydrocortisone. Like other glucocorticoids, dexamethasone has also anti-allergic, antitoxic, antishock, antipyretic and immunosuppressive properties. Dexamethasone has practically no water and salt-retaining properties; therefore particularly suitable for the use in patients with cardiac failure or hypertension.Because of the long biological half-life (36-54 hours), dexamethasone is especially suitable in conditions where continuous glucocorticoid action is desired. 

Indication:

Roxadex injections are used for the treatment of various inflammatory and autoimmune diseases e.g.:

• Rheumatism

• Collagen disease

• Allergies

• Acute adrenocortical insufficiency

Contraindications

• Systemic infection or local infection in or near a joint to be treated

• Specific anti-infective therapy is employed

• Hypersensitivity to any ingredient

Side Effect:

• Gastric duodenal ulceration, with possible hemorrhage may occasionally occur

• Hypersensitivity including anaphylaxis and allergic skin reactions

• Increased susceptibility and severity of infections due to immunosuppressive properties

• Increased intra-cranial pressure with papilloedema in children and Increased intra-ocular pressure

• Growth-retardation in infancy childhood and adolescence

• Cushingoid facies, hirsutism, weight gain, impaired carbohydrate tolerance with increased requirement for ant-diabetic therapy

Detail prescribing information:

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