Each tablet contains 0.5 mg dexamethasone BP
Dexamethasone is synthetic glucocorticoids with approximately 7 times higher anti-inflammatory potency than prednisolone and 30 times that of the hydrocortisone. Glucocorticoids act on the HPA at specific receptors on the plasma membrane. On the other tissues the glucocorticoids diffuse across cell membranes and complex with specific cytoplasmic receptors which enter the cell nucleus and stimulate protein synthesis. Like other glucocorticoids, dexamethasone has also anti-allergic, antitoxic, antishock, antipyretic and immunosuppressive properties. Dexamethasone has only minimal mineralocorticoid activity which makes it suitable for use in patients with cardiac failure or hypertension.
- Oradexon injections are used for the treatment of various inflammatory and autoimmune diseases e.g
- Oradexon also used in Ophthalmology, Haematology and Oncology.
- Gastric and duodenal ulcers
- Systemic fungal infections
- Certain viral infections, e.g. varicella and herpes genitalis infections
- Hypersensitivity to glucocorticoids.
- In general no contra-indications apply in conditions where the use of glucocorticoids may be life-saving.
The following adverse reactions have been associated with prolonged systemic glucocorticoid therapy.
Anti-inflammatory and Immunosuppressive effects: Increased susceptibility and severity of infections with suppression of clinical symptoms and signs, opportunistic infections, recurrence of dormant tuberculosis.
Neuropsychiatric: Euphoria, psychological dependence, depression, insomnia, aggravation of schizophrenia, increased intra-cranial pressure with papilloedema in children (pseudotumour cerebri) usually after withdrawal and aggravation of epilepsy.
Ophthalmic: Increased intra-ocular pressure, glaucoma, papilloedema, posterior subcapsular cataracts, corneal or scleral thinning, and exacerbation of ophthalmic viral or fungal diseases.
Dermatologic: Impaired healing, skin atrophy, bruising, telangiectasia, striae, acne.
General: Leucocytosis. Thrombo-embolism.
Detail prescribing information: