OVESTIN®

Composition:

Each tablet contains Estriol 1 mg
Cream contains Estriol 1 mg/gm

General Description

Ovestin® contains the natural hormone estriol, which is a weak estrogen. It treats urogenital symptoms without causing adverse changes to the endometrium, which means that it can be used without a progestogen in women with an intact uterus (with estrogen therapies containing estradiol, progestogens are given every month to induce a necessary protective shedding of the endometrium tissue, causing a monthly "withdrawal bleed"). The absence of progestogen-induced withdrawal bleeds with Ovestin makes it highly acceptable to women.

Indications:

• Relief of symptoms caused by atrophy of the lower urogenital tract following the menopause. These include general vaginal/urinary symptoms, recurrent infections of the vagina and lower urinary tract, and mild urinary incontinence.

• Hormone replacement therapy (HRT) for treatment of atrophic vaginitis due to estrogen deficiency in peri- and post-menopausal women

• Pre-surgery therapy for vaginal operations and during subsequent convalescence

Contraindications:

• Known or suspected breast cancer

• Known or suspected estrogen-dependent malignant tumors

• Undiagnosed genital bleeding

• Untreated endometrial hyperplasia

• Previous idiopathic or current venous thromboembolism

• Active or recent arterial thromboembolic disease

• Acute liver disease

Side effect:

• Nausea and vomiting

• Breast tenderness or pain in the breasts

• Vaginal bleeding or spotting during or on withdrawal of therapy

• Excessive production of cervical mucus

• Headache

• May cause local irritation or itching at the beginning of treatment

Detail prescribing information:

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