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ZOLETA™ is a potent and highly specific nonsteroidal aromatase inhibitor. It inhibits the aromatase enzyme by competitively binding to the haem of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. Letrozole exerts its antitumor effect by depriving estrogen dependent breast cancer cells of their growth stimulus. In postmenopausal women, estrogens are derived mainly from the action of the aromatase enzyme, which converts adrenal androgens, primarily androstenedione and testosterone to oestrone (El) and oestradiol (E2).

Product

What is Zoleta and what is it used for?

Letrozole (Zoleta) lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Before you take Zoleta, Do not take this medicine and tell your doctor if

you are allergic to any ingredient of letrozole.

Take special care while taking Zoleta

If anyone have

  • if you have not gone completely through liver disease (especially cirrhosis);
  • osteoporosis, osteopenia (low bone mineral density);
  • high cholesterol; or

if you also take tamoxifen.

How and when to take Zoleta

  • Breast Cancer
  • Endometrial carcinoma & endometrial stromal sarcoma
  •  Endometrosis
  •  Ovulation induction (Off-Label use)

 

Breast cancer :  1 tab / day for 6 months

Ovulation induction : 2.5 mg/ day 3 tablets on day 3’rd to 7’th day of menstruation (5 days)

If you forget to take Zoleta

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

If you stop taking Zoleta

It is recommended to withdraw this drug after physician consultation.

Possible side effects

Common side effects may include:

  • dizziness, drowsiness, weakness, tired feeling;
  • hot flashes, warmth in your face or chest;
  • bone pain, muscle or joint pain;
  • flushing (warmth, redness, or tingly feeling);
  • headache;
  • increased sweating; or
  • swelling, weight gain.

How to store Zoleta?

Store at room temperature (between 15-30° C)