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Angiotensin II [formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II)], is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascularsmooth muscle, adrenal gland). There is also an AT2 receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. Both losartan and its principal active metabolite do not exhibit any partial agonist activity at the AT1 receptor and have much greater affinity (about 1000-fold) for the AT1 receptor than for the AT2 receptor. In vitro binding studies indicate that losartan is a reversible, competitive inhibitor of the AT1 receptor. The active metabolite is 10 to 40 times more potent by weight than losartan and appears to be a reversible, non-competitive inhibitor of the AT1 receptor.


What is Nusartan and what is it used for?

Nusartan (Losartan) belongs to a group of drugs called angiotensin II receptor antagonists. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Before you take Nusartan, Do not take this medicine and tell your doctor if

You should not use Nusartan if you are allergic to it. If you have diabetes, do not use losartan together with any medication that contains aliskiren. Nusartan is contraindicated in pregnancy and lactation.

Take special care while taking Nusartan

Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant.

How and when to take Nusartan

Take Nusartan exactly as prescribed by your doctor. You may take losartan with or without food.

If you forget to take Nusartan

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

If you stop taking Nusartan

Do not stop taking this medicine without talking to your doctor. You should not stop taking Nusartan just because you feel better.

Possible side effects

Commonly reported side effects of losartan include: asthenia, chest pain, diarrhea, fatigue, and hypoglycemia.

How to store Nusartan

Store in a dry place, at below 30O C. Protect from light and moisture. Keep out of the reach of children.