LeneaTM stabilizes the hypothalamic-pituitary system after failure of the ovarian function in the clymactric. This central effect results from a favorable combination of hormonal properties, e.g. estrogenic, progestational and weak androgenic activities, which are demonstrated by the following effects: LeneaTM in a daily oral dose of 2.5 mg, suppresses the gonadotrophin levels in postmenopausal women and inhibits ovulation in fertile women. In this same dosage, LeneaTM does not stimulate the endometrium in postmenopausal women. Only a very few patients showed slight proliferation; the degree of proliferation did not increase with the duration of treatment. A stimulatory effect on vaginal mucosa was also seen. The same dosage of LeneaTM was shown to inhibit postmenopausal bone loss; menopausal complaints, specially vesomotor complaints such as hot flushes and sweating, are suppressed; libido and mood are favourably affected. Like other steroidal compounds, Tibolone BP is metabolized in the liver and converted to metabolites which are excreted in urine and faeces. Some of the metabolites may contribute to the biological effects of the drug.
The following medicines may interact with tibolone:
Drugs that thin the blood such as warfarin
Before taking tibolone, tell your doctor if you are allergic to it; or to other hormone replacement therapies (HRT); or if you have any other allergies.
Don’t take double dose in one day
Need to continue for 6 months
Store at room temperature, Below 25°C or in refrigerator. Do not Freeze. Protect from Sunlight and Moisture.
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