Amlodipine Besilate is a Dihydropyridine Calcium antagonist that inhibits the transmembrane influx of Calcium ions into vascular smooth muscle and cardiac muscle. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular Calcium ions into these cells through specific ion channels. Amlodipine inhibits Calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine acts directly on vessels to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Atenolol is (2- Hydroxy-3-isopropyl-aminopropoxy) phenylacetamide, a selective β1 blocker. Beta blockers are the β adrenoceptor blocking drugs, blocking the effects of adrenergic stimulation mediated through these receptors. It is devoid of intrinsic sympathomimetic activity and it decreases heart rate and cardiac output. Further, Atenolol decreases plasma renin activity.
CardifortTM Plus 25 Tablet: Each film coated tablet contains Amlodipine Besilate BP equivalent to Amlodipine 5 mg and Atenolol BP 25 mg.
CardifortTM Plus 50 Tablet: Each film coated tablet contains Amlodipine Besilate BP equivalent to Amlodipine 5 mg and Atenolol BP 50 mg.
• Hypertension not controlled by monotherapy
• Angina pectoris & hypertension co-existing diseases
• Post MI patients
• Refractory angina pectoris where nitrate therapy has failed
Amlodipine: Peripheral oedema may occasionally be present but is fully reversible. As with other calcium channel blockers peripheral oedemaand skin erythema occur in a proportion of patients and facial flushing occurs in 2-5% of patients. Complaints of fatigue were also reported more frequently than in placebo-treated patients. There is evidence that these effects are more common in patients treated with doses greater than 10 mg daily.
Atenolol: Pronounced fatigue and cold extremities have been observed in 10% to 20% of the treated subjects. Complaints of bradycardia, dizziness and gastrointestinal symptoms are less frequent. Despite its relative selectivity, Atenolol can cause bronchospasms in asthma patients. Rarely observed side effects are sleep disturbances, depressions, paraesthesia, impotence, exanthema, psoriasis exacerbations and arthropathies. Clinically relevant changes in the blood sugar have hardly occurred.
CardifortTM Plus 25 Tablet: Each box contains 30 tablets in 3 X 10's Alu-Alu blister strips.
CardifortTM Plus 50 Tablet: Each box contains 30 tablets in 3 X 10's Alu-Alu blister strips.
Mascot Plaza, 8th Floor
107/A, Sonargaon Janapath, Sector – 7, Uttara C.A
Dhaka – 1230, Bangladesh.
Phone: (+8802) 58952811, Fax: (+8802) 58955797
48, Tongi Industrial Area
Block-C, Tongi, Gazipur.
Phone: (+8802) 980 2387, Fax: (+8802) 980 2387