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Cefuroxime Axetil is an orally active prodrug of Cefuroxime.  After oral administration, Cefuroxime Axetil is absorbed from the gastrointestinal tract and rapidly hydrolyzed by nonspecific esterases in the intestinal mucosa and blood to release Cefuroxime into the blood stream. Conversion to Cefuroxime, the microbiologically active form, occurs rapidly. The inherent properties of Cefuroxime are unaltered after its administration as Cefuroxime Axetil.  Cefuroxime exerts its bactericidal effect by binding to an enzyme or enzymes referred to as penicillin-binding proteins (PBPs) involved in bacterial cell wall synthesis.

Product

Composition

Axibid 500 mg tablet: Each tablet contains Cefuroxime Axetil USP equivalent to 500 mg Cefuroxime.
Axibid 250 mg tablet: Each tablet contains Cefuroxime Axetil USP equivalent to 250 mg Cefuroxime.

Indication

Axibid (Cefuroxime Axetil) is indicated in the treatment of:
• Upper respiratory tract infections: for example, ear, nose and throat infections such as otitis media, sinusitis, tonsillitis and pharyngitis.
• Lower  respiratory  tract  infections:  for  example,  acute  bronchitis,  acute  exacerbations  of chronic bronchitis and pneumonia.
• Skin and soft tissue infections: such as furunculosis, pyoderma, and impetigo.
• Genito-urinary tract infections: such as pyelonephritis, urethritis, and cystitis.
• Gonorrhoea: acute uncomplicated gonococcal urethritis, and cervicitis.
• Early Lyme disease & subsequent prevention of late Lyme disease.

Side Effects

Generally Cefuroxime is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.

Commercial Pack

Axibid 500 mg tablet: Each box contains 1 x 7 tablets in Alu-Alu blister strip.

What is (Axibid) and what is it used for?

Axibid (Cefuroxime axetil) is a well-characterized and effective antibacterial agent, which has broad-spectrum bactericidal activity against a wide range of common pathogens, including beta-lactamase-producing strains. It is very effective for various types of infections such as-

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Skin and soft tissue infections
  • Genito-urinary tract infections

Gonorrhea: acute uncomplicated gonococcal urethritis, and cervicitis

Before you take (Axibid), Do not take this medicine and tell your doctor if

Axibid (Cefuroxime Axetil) is contraindicated in-patients with known allergy to cephalosporins.

Take special care while taking (Axibid)

Prolonged use of Cefuroxime axetil may result in the over growth of non-susceptible organisms (e. g. Candida, Enterococci, Clostridium difficile), which may require interruption of treatment

How and when to take (Axibid)

Most infections will respond to 250 mg b. d. In mild to moderate lower respiratory tract infections, e.g. bronchitis, 250 mg b. d. should be given. For more severe lower respiratory tract infections, or if pneumonia is suspected then 500 mg b.d. should be given. For urinary tract infections a dose of 125 mg b. d. is usually adequate; in pyelonephritis the recommended dose is 250 mg b. d. A single dose of one gram is recommended for the treatment of uncomplicated gonorrhoea. Lyme disease in adults and children over the age of 12 years: the recommended dose is 500 mg b .d. for 20 days.

 

There is no experience in children under three months of age.

The usual course of therapy is seven days.

Cefuroxime should be taken after food for optimum absorption.

If you forget to take (Axibid)

Take your missed dose as soon as you remember or, if it is nearly time for your next dose, skip your missed dose altogether

If you stop taking (Axibid)

Do not stop taking this medicine without talking to your doctor. You should not stop taking (Axibid) just because you feel better. Patient has to complete full dosage. This is because the problem may come back or get worse again.

Possible side effects

Cefuroxime axetil has been associated with nausea and vomiting in a small number of patients

How to store (Axibid)

Store in a cool (below 30°C), dry place & protect from light. Keep out of the reach of children